Quinazoline compound and anti-tumor agent containing said compou

Details Quinazoline compound and anti-tumor agent containing said compou Quinazoline compound and anti-tumor agent containing said compou

1997-08-20

1999-06-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544287, A61K 31505, C07D40304

Patent

active

059122471

ABSTRACT:
A quinazoline compound of the formula (I): ##STR1## wherein Z means a group of the formula: ##STR2## (X is CH.sub.2, CHOH, CHOCH.sub.3, or O, and n is 1 to 3), or a group of the formula: ##STR3## (A is H or CH.sub.3, and B is --CH.sub.2 OH, or ethyl having 1 or 2 OH, or propyl having 2 or 3 OH), or a salt thereof, which are useful as anti-tumor agent, and a pharmaceutical composition containing the compound as an active ingredient.

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Cancer Chemotherapeutic Agents, Medical Research Inc., Japan, pp. 446-447, Feb. 20, 1993.
Hori, et al., Novel 4-Substituted 2-Piperazinylquinazolines as Potent Anticonvulsive and Anthiypoxic Agents, Chem. Pharm. Bull, 38, (5), 1990, pp. 1286-1291.
Hori, et al., "Potential Nootropic Agents, 4-Alkoxy-2-(1-piperaxinyl)quinazoline Derivatives", Chem. Pharm. Bull, 39, (2), 1991, pp. 367-371.

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