Quinazoline analogs as receptor tyrosine kinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S266230, C544S284000, C544S293000

Reexamination Certificate

active

07452895

ABSTRACT:
This invention provides quinazoline analogs of Formula I:where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

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First Office Action from the Chinese State Intellectual Property Office (SIPO) dated Mar. 14, 2008.

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