Quinate salts of the antimalarial compound mefloquine

Details Quinate salts of the antimalarial compound mefloquine Quinate salts of the antimalarial compound mefloquine

1984-02-27

1985-06-04

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546176, C07D40106, A61K 3147

Patent

active

045214247

ABSTRACT:
The compound of formula (I) ##STR1## possesses markedly increased solubility under aqueous conditions and improved pharmacokinetic profile against malaria-causing parasites. Pharmaceutical compositions and method of treatment of subjects with malaria are also disclosed.

REFERENCES:
patent: 4284627 (1981-08-01), Raether et al.
Am. J. Trop. Med. Hyg., 32(3), 1983, pp. 447-451.
Ohnmacht et al., J. Med. Chem., vol. 14, No. 10, pp. 926-928, (1971).

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