Quinate salts of antimalarial phenanthrenemethanol compounds

Details Quinate salts of antimalarial phenanthrenemethanol compounds Quinate salts of antimalarial phenanthrenemethanol compounds

1983-11-02

1989-04-04

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

26050118, 514653, 514895, 564355, A61K 31205

Patent

active

048187674

ABSTRACT:
The compounds of formula (I) ##STR1## wherein R.sub.1 is hydrogen or an alkyl radical containing one to six carbon atoms and R.sub.2 is an alkyl radical containing one to six carbon atoms possess markedly increased activity against malaria-causing parasites. Pharmaceutical compositions and method of treatment of subjects with malaria are also disclosed.

REFERENCES:
patent: 3097243 (1963-07-01), Cutler
patent: 4178376 (1979-12-01), Higuchi et al.
Am. J. Trop. Med. Hyg., 31(6), 1982, pp. 1075-1079.
Am. J. Trop. Med. Hyg., 25(6), 1976, pp. 769-774.
J. Med. Chem., 15(7), 1972, pp. 771-775.
Annals Trop Med. Para., 73(6), 1979, pp. 505-525.

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