Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2005-03-29
2005-03-29
Spear, James M. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S439000, C424S440000, C424S441000, C424S465000
Reexamination Certificate
active
06872405
ABSTRACT:
The present invention relates to a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent, which is obtained by uniformly mixing the saccharide with a low melting point in the tablet so that a bridge will be formed between said drug and/or said diluent particles by the product of melting and then solidification of this saccharide with a low melting point. Moreover, the present invention relates to a method of manufacturing a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent and a saccharide with a relatively lower melting point than the drug and the diluent, which comprises (a) the process whereby tablet starting materials including a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent are molded under the low pressure necessary for retaining the shape of a tablet, (b) the process whereby the molded product obtained in process (a) is heated to at least the temperature at which this saccharide with a low melting point will melt, and (c) the process whereby the molded product obtained in process (b) is cooled to at least the temperature at which the molten saccharide with a low melting point solidifies. The present invention presents a quick-disintegrating tablet in the buccal cavity that can be used for practical purposes in that it has almost the same properties as conventional oral pharmaceutical tablets, that is, it has sufficient tablet strength that it can be used with automatic unit dosing machines, and it is produced by conventional tableting machines, and a manufacturing method thereof. Moreover, the present invention presents a quick-disintegrating tablet in the buccal cavity which, in comparison to conventional quick-disintegrating tablets in the buccal cavity, has increased tablet strength and an improved friability without prolonging the disintegration time in the buccal cavity, and a manufacturing method thereof.
REFERENCES:
patent: 5534555 (1996-07-01), Meggelaars et al.
patent: 5576014 (1996-11-01), Mizumoto et al.
patent: 5837285 (1998-11-01), Nakamichi et al.
patent: 6039813 (2000-03-01), Pepper et al.
patent: 6083438 (2000-07-01), Gonze et al.
patent: 6413541 (2002-07-01), Shirai et al.
patent: 20020071865 (2002-06-01), Kajiyama et al.
patent: 1 022 021 (2000-07-01), None
patent: 1072256 (2001-01-01), None
patent: 2 786 665 (2000-06-01), None
patent: 1 084 864 (1967-09-01), None
patent: A-H4-505918 (1992-10-01), None
patent: A-H5-170669 (1993-07-01), None
patent: A-H5-310558 (1993-11-01), None
patent: A-H9-309822 (1997-12-01), None
patent: 11-33084 (1999-02-01), None
patent: 11-35451 (1999-02-01), None
patent: A-H11-263723 (1999-09-01), None
patent: A-2001-58944 (2001-06-01), None
patent: WO 9313758 (1993-07-01), None
patent: WO 9520380 (1995-08-01), None
patent: WO 9943306 (1999-09-01), None
patent: WO 0004880 (2000-02-01), None
patent: WO 0232403 (2002-04-01), None
Copy of Search Report for Corresponding PCT application, PCT/JP02/04481.
Masuda Yoshinori
Mizumoto Takao
Takaishi Yuuki
Spear James M.
Townsend and Townsend / and Crew LLP
Yamanouchi Pharmaceutical Co. Ltd.
LandOfFree
Quick-disintegrating tablet in buccal cavity and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Quick-disintegrating tablet in buccal cavity and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quick-disintegrating tablet in buccal cavity and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3405973