Quaternary salts of para-dialkylamino benzamide derivatives

Details Quaternary salts of para-dialkylamino benzamide derivatives Quaternary salts of para-dialkylamino benzamide derivatives

1993-08-25

1995-09-19

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

Aromatic acid or derivative containing

424 47, 424 709, 514938, 544 581, 544165, 546221, 546233, 548146, 548215, 548567, 564163, C07D24900, C07C23377, A61K 706, A61K 742

Patent

active

054513944

ABSTRACT:
This invention relates to non-hydrolyzable, non-irritating, hair, skin and textile substantive quaternary ammonium salts of a para-dialkylamino benzamide having the formula ##STR1## wherein R' and R" are each selected from the group of C.sub.1 to C.sub.2 alkyl; n is an integer having a value of from 2 to 6; R is an alkyl radical having from 1 to 30 carbon atoms; R.sub.1 and R.sub.2 are each selected from the group of C.sub.1 to C.sub.4 alkyl, hydrogen and, alternatively, R.sub.1 and R.sub.2, together with the attached cationic nitrogen atom can form a 5 to 6-membered heterocyclic ring selected from the group of ##STR2## and X is an anion. These benzamide derivatives are active sunscreening agents which are usefully employed at a concentration of from about 0.5 to about 10 wt. % in a formulation requiring protection against the harmful effects of sunlight, such as skin burn, hair damage, color fading, etc.

REFERENCES:
The Merck Index, 10th Ed., (1983), p. 1116, item 7658.
Steen, et al., C.A.; 118:51841 (1992).
Kimura, et al., C.A.; 109:31538 (1988).
Schanker, et al., C.A.; 104:61509 (1986).
Eaton, et al., C.A.; 89:208889 (1978).

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