Quaternary derivatives of noroxymorphone which relieve nausea an

Details Quaternary derivatives of noroxymorphone which relieve nausea an Quaternary derivatives of noroxymorphone which relieve nausea an

1986-03-07

1988-01-12

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

047192151

ABSTRACT:
Quaternary derivatives of noroxymorphone are used to prevent or relieve nausea and emesis associated with the use of narcotic analgesics without interfering with the analgesic activity of the drugs. A particularly preferred compound is methylnaltrexone. The compound is administered in a concentration between 0.25 mg/kg and 1.0 mg/kg prior to or concurrently with the administration of the narcotic analgesic.

REFERENCES:
patent: 4176186 (1979-11-01), Goldberg et al.

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