Quaternary cytofectins

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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435 6, 435455, 435458, 435325, 424 121, 424 9321, 424417, 424420, 427 214, 3574022, A61K 4800

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active

059943173

ABSTRACT:
Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having functional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.

REFERENCES:
patent: 2368208 (1945-01-01), Epstein
patent: 3265719 (1966-08-01), Cowen et al.
patent: 4864060 (1989-09-01), Karalis et al.
patent: 5049386 (1991-09-01), Eppstein et al.
patent: 5068431 (1991-11-01), Karalis et al.
patent: 5144060 (1992-09-01), Morita et al.
patent: 5264618 (1993-11-01), Felgner et al.
patent: 5279833 (1994-01-01), Rose
patent: 5334761 (1994-08-01), Gebeyehu et al.
patent: 5459127 (1995-10-01), Felgner et al.
patent: 5614548 (1997-03-01), Piantadosi et al.
patent: 5753613 (1998-05-01), Ansell et al.
Bhattacharya et al. (Chemistry and Physics of Lipids, 78, 177-188, 1995).
Bhattacharya et al. (Langmuir, 11, 4748-4757, 1995).
Guo et al. (J. Liposome, 3, 1, 51-70, 1993, HCAPLUS, AN: 1993:546446).
Dorn et al., Chem., Rapid Commun, 4, 8, 513-17, HCAPLUS, AN: 1983:535872.
Wheeler et al. (Biochim. et Biophsica Acta 1280, 1996, 1-11).
Meyer et al. (J. Med. Chem., 1991, 34:1377-1383).
"Synthesis of Amphiphilic Piperidinium Derivatives. Cationic Lipids 4.sup.1," Solodin, Igor and Heath, Timothy D., Synlett, p. 619, Jul. 1996 (received for publication Oct. 11, 1995).
"Synthesis of Amphiphilic Derivatives of N-Methyldiethanolamine. Cationic Lipids 5.sup.1," Solodin, et al., Synlett, p. 620, Jul. 1996 (received for publication Oct. 11, 1995).
"Synthesis of Novel Cationic Lipids with a Guanidine Group. Cationic Lipids 3.sup.1," Solodin, Igor and Heath. Timothy D., Synlett, pp. 617-618, Jul. 1996 (received for publication Sep. 19, 1995).
S. L. Morris-Natschke, et al., Synthesis of phosphocholine and quaternary amine ether lipids and evaluation of in vitro antineoplastic activity, Journal of Medicinal Chemistry, vol. 36, No. 14, pp. 2018-2025, (1993).
I. Solodin, et al. "Synthesis of amphiphilic derivatives of N-methyldiethanolamine. Cationic lipids. 5", Synlett, p. 620, (Jul. 1996).
Y. Fukuyama, et al., "Electroviscous fluids for clutch or shock absorbers", Chemical Abstracts, vol. 116, No. 16, p. 203, abstract No. 155243u, Apr. 20, 1992.
I.P. Komkov, et al., "Surface-active quaternary ammonium salts.", Chemical Abstracts, vol. 77, No. 22, p. 92, abstract No. 141711j, Nov. 27, 1972.
H. Distler, et al., "Biocidal surfactants", Chemical Abstracts, vol. 71, No. 23, p. 113, abstract No. 110160a, Dec. 8, 1969.
G. Nabel, et al., "Immunotherapy of Malignancy by In Vivo Gene Transfer into Tumors", Human Gene Therapy, 3:399-410, (1992).
A. Rosenthal, et al., "A Synthetic Inhibitor of Venom Lecithinase A*", The Journal of Biological Chemistry, vol. 235, No. 8, (1960).
P. Felgner, et al., "Lipofection: A highly efficient, lipid-medicated DNA-transfection procedure", Proc. Natl. Acad. Sci. USA, 84:7413-7417 (1987).
J. Felgner, et al., "Enhanced Gene Delivery and Mechansim Studies with a Novel Series of Cationic Lipid Formulations*", The Journal of Biological Chemistry, 269:2550-2561 (1994).
C. Wheeler, et al., "Converting an alcohol to an amine in a cationic . . . ultrastructure of DNA-cytofectin complexes", BBA, 1280:1-11 (1996).

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