Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2006-04-11
2006-04-11
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S181000, C562S455000, C544S059000, C544S168000, C546S216000, C546S224000, C546S225000, C514S227500, C514S237800, C514S327000, C514S329000, C514S330000, C514S538000, C514S617000, C514S619000
Reexamination Certificate
active
07026510
ABSTRACT:
(R)-Enantiomers of quaternary ammonium salts of general formula (I) are described:where R, R1, R2, R3, X and Z are as defined in the description.The process for their preparation and pharmaceutical preparations thereof are also described.The quaternary salts of the invention are useful in the inhibition of chemotaxis of neutrophils and monocytes induced by the fraction C5a of the complement and are used in the treatment of psoriasis, pemphigus and pemphigoid, rheumatoid arthritis, intestinal chronic inflammatory pathologies including ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, cystic fibrosis, chronic obstructive pulmonary disease and glomerulonephritis.The compounds of the invention are advantageously used in the prevention and the treatment of injury caused by ischemia and reperfusion.
REFERENCES:
patent: 2002/0160988 (2002-10-01), Amitai et al.
patent: 1 593 024 (1970-05-01), None
patent: 2 410 641 (1979-06-01), None
patent: WO 01 58852 (2001-08-01), None
patent: WO 02 068377 (2002-09-01), None
Allegretti Marcello
Bertini Riccardo
Bizzarri Cinzia
Cesta Maria Candida
Birch & Stewart Kolasch & Birch, LLP
Dompe S.p.A.
Kumar Shailendra
LandOfFree
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