Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-08-19
2000-08-01
Lambkin, Deborah C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514450, 514617, 549 12, 549355, 564180, A61K 3138, A61K 31335, A61K 31165, C07D33712, C07D31300
Patent
active
060967803
ABSTRACT:
This invention is to provide a compound for antagonizing CCR5, said compound being represented by the formula: ##STR1## wherein R.sup.1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is --CH.sub.2 --, --S-- or --O--; and R.sup.2, R.sup.3 and R.sup.4 are independently an optionally substituted aliphatic hydrocarbon group or an optionally substituted alicyclic heterocyclic ring group, and being effective for the prevention and treatment of infectious disease of HIV.
REFERENCES:
patent: 5922771 (1999-07-01), Ohkawa et al.
patent: 6013809 (2000-01-01), Zimmer et al.
English Abstract of JP-A-25756/1995.
English Abstract of JP-A-25757/1995.
M. Baba et al. "A small-molecule, nonpeptide, CCR5 antagonist with highly potent and selective anti-HIV-1 activity", Proc. Natl. Acad. Sci., vol. 96, pp. 5698-5703, May 1999.
Aramaki Yoshio
Baba Masanori
Kanzaki Naoyuki
Nishimura Osamu
Shiraishi Mitsuru
Lambkin Deborah C.
Takeda Chemical Industries Ltd.
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