Quaternary ammonium antiarrhythmic drugs

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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564282, 564284, 564287, 564289, A61K 3114, C07C 8500, C07C 8700, C07C 9300

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active

042897874

ABSTRACT:
Quaternary ammonium salts of certain phenylbutylamines are useful antiarrhythmic drugs. A method for treating arrhythmia and prolonging the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such quaternary ammonium salts are disclosed.

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patent: 3972935 (1976-08-01), Molloy
patent: 4001433 (1977-01-01), Maxwell et al.
patent: 4034011 (1977-07-01), Molloy
Pharmac 37, 555-584, 1969--Barlow et al.
European J. of Pharm. 35 (1976), 245-252--Lien et al.
Chem. Abst. 54, 19588(f) (1960)--Morikawa.

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