Quarternary pyridinium salts

Details Quarternary pyridinium salts Quarternary pyridinium salts

1989-10-04

1992-01-07

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546147, 546169, 546174, 546286, 546287, 546288, 546291, 546294, 546295, 546296, 546298, 546299, 546300, 546315, 546316, 546318, 546321, 546322, 546323, 546326, 546328, 546335, C07D21538, C07D21362, C07D21370, C07D21356

Patent

active

050793667

ABSTRACT:
The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine.revreaction.pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.

REFERENCES:
patent: 3929813 (1975-12-01), Higuchi et al.
patent: 3962447 (1976-06-01), Higuchi et al.
patent: 4530920 (1985-07-01), Nestor et al.
patent: 4540564 (1985-09-01), Bodor
patent: 4565804 (1986-01-01), Rivier et al.
patent: 4567162 (1986-01-01), de Castiglione et al.
patent: 4568754 (1986-02-01), Laruelle et al.
patent: 4569927 (1986-02-01), Rivier et al.
patent: 4619915 (1986-10-01), Ives
patent: 4638046 (1987-01-01), Verdini et al.
Bodor et al., J. Pharm. Sci., 67, No. 5, 685-687 (1978).
Bodor, "Novel Approaches for the Design of Membrane Transport Properties of Drugs", in Design of Biopharmaceutical Properties Through Prodrugs and Analogs, Roche, E. B. (ed.), APhA Academy of Pharmaceutical Sciences, Washington, D.C., 98-135 (1976).
Bodor et al., Science, vol. 214, Dec. 18, 1981, pp. 1370-1372.
Bodor et al., Pharmacology and Therapeutics, vol. 19, No. 3, pp. 337-386 (1983).
The Friday Evening Post, Aug. 14, 1981, Health Center Communications, University of Florida, Gainesville, Florida.
Chemical & Engineering News, Dec. 21, 1981, pp. 24-25.
Science News, Jan. 2, 1982, vol. 121, No. 1, p. 7.
J. S. Morley, Annu. Rev. Pharmacol. 20: 81-110 (1980).

Affiliated with

Also associated with

Rating

Quarternary pyridinium salts does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quarternary pyridinium salts, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quarternary pyridinium salts will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-823509