Quantitative testing for vitamin B.sub.12

Details Quantitative testing for vitamin B.sub.12 Quantitative testing for vitamin B.sub.12

1978-04-04

1980-02-12

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

23230B, 232306, 424 1, 424 96, 435 7, G01N 3316, G01N 3106

Patent

active

041881893

ABSTRACT:
Errors in the radioisotope dilution assay (RIDA) of the vitamin B.sub.12 level of human blood have been traced to the presence of vitamin B.sub.12 analogues. These previously unrecognized analogues bind with proteins normally included with binding proteins used in the prior art RIDA techniques. The errors caused by the B.sub.12 analogues are avoided by using a composition for binding vitamin B.sub.12 which is substantially free of substances which bind vitamin B.sub.12 analogues. Moreover, by using both types of binders in separate assays, the amount of analogue present may be arrived at by taking the difference of the assays. Compositions that are effectively substantially pure intrinsic factor (IF) are used as binders.

REFERENCES:
patent: 3434927 (1969-03-01), Highley
patent: 3442819 (1969-05-01), Herbert
patent: 3937799 (1976-02-01), Lewin

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