Quantitative pulmonary imaging

Details Quantitative pulmonary imaging Quantitative pulmonary imaging

2005-07-05

2005-07-05

Shaw, Shawna J. (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C424S009300, C324S307000, C324S309000

Reexamination Certificate

active

06915151

ABSTRACT:
The present invention comprises imaging and quantitative measurement of lung ventilation, particularly in a human lung. Methods for quantitative imaging of lung ventilation, and the further provided systems and algorithmic tools therefore, comprise three primary components: the combined MRI ventilation/perfusion (V/Q) imaging techniques using hyperpolarized helium-3 (3He) gas (H3He); the three-dimensional quantitative imaging of absolute lung perfusion (Q) and collection of local magnetic resonance image data therefrom to produce an absolute lung perfusion image data; and the algorithmic co-registration of the two image data sets, (HP-3He MRI image of V/Q and MR imaging of quantitative perfusion (Q) in the lung). From the data acquired in the combined data sets and their spatial co-registration, absolute ventilation (V) is computed.

REFERENCES:
patent: 5402785 (1995-04-01), Leigh et al.
patent: 5974165 (1999-10-01), Giger et al.
patent: 6271665 (2001-08-01), Berr et al.
patent: 6370415 (2002-04-01), Weiler et al.
patent: 6426058 (2002-07-01), Pines et al.
patent: 2003/0023162 (2003-01-01), Baumgardner et al.
patent: 2003/0064023 (2003-04-01), Driehuys et al.
Cremillieu et al. “A Combined 1H Perfusion/3HE Ventilation NMR Study in Rat Lungs” Magnetic Resonance in Medicine 41:645-648 (1999).
Maki et al. “Recent Advances in Pulmonary Imaging” Chest; Nov. 1999; 116, 5 pp. 1388-1402.
Viallon et al. “Laser-Polarized 3He as a Probe for Dynamic Regional Measurements of Lung Perfusion and Ventilation Using Magnetic Resonance Imaging” Magnetic Resonance in Medicine 44:1-4 (2000).
Hatabu et al. “Quantitative Assessment of Pulmonary Perfusion With Dynamic Contrast-Enhanced MRI” Magnetic Resonance in Medicine 42:1033-1038 (1999).
Rizi et al. “Co-registration of Acquired MR Ventilation and Perfusion Images—Validation in a Porcine Model” Magnetic Resonance in Medicine 49: 13-18 (2003).
Rizi et al. “Determination of Regional Va/Q by Hyperpolarized 3He MRI” Magnetic Resonance in Medicine 52:65-72 (2004).
Altes, T.A., et al, “Hyperpolarized3He MR Lung Ventilation Imaging in Asthmatics: Preliminary Findings,”J. Mag. Res. Imag. 13(3):378-384 (2001).
Black,R.D., et al, “In vivo He-3 MR Images of Guinea Pig Lungs,”Rad199(3):867-870 (1996).
de Lange, E.E., et al, “Lung Air Spaces: MR Imaging Evaluation With Hyperpolarized 3He Gas,”Rad210(3):851-857 (1999).
Gierada, D.S., et al, “Dynamic Echo Planar MR Imaging of Lung Ventilation With Hyperpolarized (3)He in Normal Subjects and Patients With Severe Emphysema,”NMR Biomed. 13(4):176-181 (2000).
Kauczor, H.U., et al, “Imaging of the Lungs Using 3He MRI: Preliminary Clinical Experience in 18 Patients With and Without Lung Disease,”J. Mag. Res. Imag. 7:538-543 (1997).
Kauczor, H.U., et al, “Normal and Abnormal Pulmonary Ventilation: Visualization at Hyperpolarized He-3 MR Imaging,”Rad201:564-568 (1996).
MacFall, J.R., et al, “Human Lung Air Spaces: Potential For MR Imaging With Hyperpolarized He-3,”Rad200:553-558 (1996).
Middleton, H., et al, “MR Imaging With Hyperpolarized3He Gas,”Mag. Res. Med. 33:271-275 (1995).
Roberts, D.A., et al, “Detection and Localization of Pulmonary Air Leaks Using Laser-Polarized Helium-3 MRI,”Mag. Res. Med. 44(3):379-382 (2000).
Salerno, M., et al, “Dynamic Spiral MRI of Pulmonary Gas Flow Using Hyperpolarized3He:Preliminary Studies in Healthy and Diseased Lungs,”Mag. Res. Med. 46:667-677 (2001).

Affiliated with

Also associated with

Rating

Quantitative pulmonary imaging does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quantitative pulmonary imaging, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quantitative pulmonary imaging will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3414855