Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2005-04-06
2011-11-01
Chen, Tse (Department: 3768)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C382S128000
Reexamination Certificate
active
08047993
ABSTRACT:
Disclosed is a method for detecting the degree of malignancy in tumors noninvasively, which comprises the steps of: using a Power Doppler ultrasound unit to scan a tumor and capture sequential color imagines in a complete heartbeat cycle, and choosing an area of interest (AREA_ROI) from the images; labeling pixels reflecting signals of bloodflow in the imagines during one heartbeat cycle to contour an area of tumor blood vessels (AREA_vessel); calculating a difference of PDVI between maximal systolic pressure and diastolic pressure during the heartbeat cycle to obtain tumor differential vascularity index (TDVI), in which PDVI is the ratio obtained by dividing pixels of AREA_vessel by a total area in the section of AREA_ROI; and determining the degree of malignancy by the TDVI. The method of the present invention can be applied to monitor the response of tumor to clinical treatment.
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Chang King-Jen
Chen Chiung-Nein
Hsieh Fon-Jou
Pao Sun-Hua
Shau Yio-Wha
Birch & Stewart Kolasch & Birch, LLP
Bor Helene
Chen Tse
Industrial Technology Research Institute
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