Quantitative method of measuring metastatic activity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 723, 436 64, C12Q 168, G01N 33574, G01N 3348

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active

058692380

ABSTRACT:
The metastatic potential of tumors can be evaluated by the quantitative detection of urokinase and DNA. The cell sample selected for examination is analyzed for the presence of high levels of urokinase and abnormal DNA using analytical flow cytometry and digital image analysis. Other factors such as membrane associated urokinase, increased DNA synthesis rates and certain receptors can be used in the method for detection of potentially invasive tumors.

REFERENCES:
patent: 4276375 (1981-06-01), Claeson et al.
patent: 4668618 (1987-05-01), Thornthwaite
patent: 4741043 (1988-04-01), Bacus
patent: 4752583 (1988-06-01), Jensen et al.
patent: 4780406 (1988-10-01), Dolbeare et al.
patent: 4808528 (1989-02-01), Tryggvason et al.
Suzuki et al. "An introduction to Genetic analysis." Foruth Ed. Freeman and Co., NY. pp. 207-212 and 722, 1989.
Merkel, D.E., Therapy of Breast Cancer, Genoa, Italy, Meeting Abstract, Sep. 1989.
Hollas, W. et al, Cancer Research, vol. 51, pp. 3690-3695, Jul. 1991.
Rao, J.Y. et al, Cancer Research, vol. 50, pp. 2215-2220, Apr. 1990.
Spyratos, F. et al., Proc. Annu. Meet. Am. Cancer Res., vol. 33, A1579, 1992.
Spyratos, F. et al., J. of the Nat. Cancer Inst., vol. 84, No. 16, pp. 1266-1272, Aug. 1992.
"Plasminogen Activator Content Of Gynecological Tumors And Their Metastases", Gynecologic Oncology 26: 364-373, S.M. Camiolo, G. Markus, & M. S. Piver, 1987.
"Comparative Study Of Plasminogen Activators In Cancers And Normal Mucosae Of Human Urinary Bladder", Cancer Research 49: 1067-1070, Y. Hasui et al, Feb. 15, 1989.
"Secretion Of Plasminogen Activators By Human Colorectal And Gastric Tumor Explants", Clin. Expl. Metastasis 6: 431-450, S. R. Harvey et al, 1988.
"Urokinase-type Plasminogen Activator (u-PA) Antigen is a Predictor of Early Relapse in Breast Cancer," Fibrinolysis 4: 69-78, F. Janicke et al, 1990.
"Tumour-Associated Fibrinolysis: The Prognostic Relevance Of Plasminogen Activators uPA and tPA in Human Breast Cancer", Blood Coagulation and Fibrinolysis 1: 695-702, 1990.
"Plasminogen Activator Secretion of Human Tumors in Short-Term Organ Culture, Including a Comparison of Primary and Metastatic Colon Tumors", Cancer Research 43: 5517-5525, G. Markus et al, 1983.
"Receptor-Medicated Internalization and Degradation of Urokinase is Caused by Its Specific Inhibitor PAI-1", EMBO Journal 9: 1079-1085, M.V. Cubellis, T. Wun, & F. Blasi, 1990.
"Flow Cytometry, Cellular DNA Content and Prognosis in Human Malignancy", J. Clin. Ocnology 5: 1690-1703, D. E. Merkel, L. G. Dressler and W. L. McGuire, 1987.
"An Immunofluorescence Method for Monitoring DNA Synthesis by Flow Cytometry", Cytometry 6: 385-389, H. G. Gratzner and R. C. Leif, 1981.
"Urokinase-Plasminogen Activator, a New and Independent Prognostic Marker in Breast Cancer", Cancer Research 50, pp. 6827-6829, Michael J. Duffy et al, 1990.
"Flow Cytometry", Arch Pathol Lab Med, vol. 107, pp. 1-6, Raul C. Braylan, MD, 1983.
"Measuring the Metastatic Potential of Cancer Cells", Technology 2002, Dennis R. Morrison et al, 2 pages, Balitmore, MD, Dec. 1992.

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