Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-04-03
2000-11-21
Minnifield, Nita
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 79, 435 792, 435 793, 4241841, 514866, 514 56, G01N 3353, G01W 33535, A61K 3900, A61K 3938
Patent
active
061501158
ABSTRACT:
The present invention relates to a quantitative determination method for heparan sulfate in body fluid specimens of various chronic diseases, in urine samples of diabetic nephropathy and for diagnosing hepatic diseases and rheumatoid arthritis in blood specimens. And also this method provides a diagnostic tool for judging the condition of diabetic nephropathy, hepatic diseases and rheumatoid arthritis by determination of changes by use of aforementioned quantitative determination of heparan sulfate.
REFERENCES:
Yokoyama et al, The 11th Diabetic Nephropathy Meeting held in Nagoya, Japan on Oct. 4-5, 1997.
Satoh et al, The 9th Japan Diabetic Nephropathy Seminar Abstracts in Tokyo, Japan on Nov. 15-16, 1997.
Product Report No. 90, Sep. 1, 1995, Seikagacu Corporation (with English subtitles).
Jacob van Den Born, et al., A Monoclonal antibody agaist GBM heparan sulfate induces an acute selective proteinuria in rats, International Society of Nephrology, Kidney international, vol. 41(1992), pp. 115-123.
J.T. Tamsma, et al., Expression of glomerular extracellular matrix components in human diabetic nephropathy: decrease of heparan sulphate in the glomerular basement membrane. Diabetologia (1994)37:313-320.
J. van den Born, et al., Selective proteinuria in diabetic nephropathy in the rat is associated with a relative decrease in glomerular basement membrane heparan sulphate, Diabetologia (1995)38:161-172.
Nicole F. van Det, et al., Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and epithelial cells. International Society of Nephrology, Kidney International, vol. 49(1996), pp. 1079-1089.
Diabetes, The 40th Japan Diabetes Associate annual Learning Meeting Program & Abstracts, May 22-24, 1997 at Tokyo, Japan, Japan Diabetes Associate, Issued Apr. 21, 1997.
The 11th Diabetic Nephropathy Meeting held in Nagoya, Japan on Oct. 4-5, 1997.
The 9th Japan Diabetic Nephropathy Seminar Abstracts in Tokyo, Japan on Nov. 15-16, 1997.
The 12th Japan Diabetic Animal Seminar Program Lecture Abstract in Osaka, Japan on Feb. 6-7, 1998.
The 41th Japan Diabetes Associate Annual Learning Meeting Pamphlet in Wakayama, Japan on May 20-21, 1998.
Product Report No. 10 Monoclonal Anti Heparan Sulfate, 10E4, Monoclonal Anti Heparan sulfate, 3G10 by Seikagaku Corporation.
J. Van Den Born, et al., Production and Characterization of a Monoclonal antibody Against Human Glomerular Heparan Sulfate, Laboratory Investigation, vol. 65, No. 3, pp. 287-297, 1991.
Ishimaru Takeshi
Miyaura Shuichi
Takeshita Sawako
Baskar Padma
Minnifield Nita
Seikagaku Kogyo Kabushiki Kaisha
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