Quantitative assay for low abundance molecules

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

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C435S006120, C435S007100, C435S287200, C435S287900, C435S803000, C436S513000, C436S161000, C210S365000, C210S656000

Reexamination Certificate

active

07074586

ABSTRACT:
A method for quantitatively assaying one or more target molecules in a sample uses a nucleic acid aptamer that is specific for each target molecule. A quantitative replicative procedure is used to determine a quantity of aptamer specific for each molecule.

REFERENCES:
patent: 3957436 (1976-05-01), Murray
patent: 4081246 (1978-03-01), Polito et al.
patent: 4517303 (1985-05-01), Freytag et al.
patent: 4623618 (1986-11-01), Rokugawa
patent: 4769216 (1988-09-01), Chandler et al.
patent: 4943525 (1990-07-01), Dawson
patent: 5173293 (1992-12-01), Friend et al.
patent: 5246832 (1993-09-01), Michelson et al.
patent: 5273882 (1993-12-01), Snitman et al.
patent: 5534407 (1996-07-01), Tabor et al.
patent: 5567588 (1996-10-01), Gold et al.
patent: 5582981 (1996-12-01), Toole et al.
patent: 5583005 (1996-12-01), Nishimura et al.
patent: 5646001 (1997-07-01), Terstappen et al.
patent: 5674727 (1997-10-01), Cole et al.
patent: 5756291 (1998-05-01), Griffin et al.
patent: 5866336 (1999-02-01), Nazarenko et al.
patent: 5989823 (1999-11-01), Jayasena et al.
patent: 6054274 (2000-04-01), Sampson et al.
patent: 6180348 (2001-01-01), Li
patent: 6180415 (2001-01-01), Schultz et al.
patent: 6242246 (2001-06-01), Gold et al.
patent: 6281245 (2001-08-01), Patel et al.
patent: 6287765 (2001-09-01), Cubicciotti
patent: 2002/0051974 (2002-05-01), Dodge et al.
patent: WO91/19813 (1991-12-01), None
patent: WO 95/07364 (1995-03-01), None
patent: WO 96/10576 (1996-04-01), None
patent: WO 99/07724 (1999-02-01), None
Bieche et al. Novel approach to quantitative polymerase chain reaction using real-time detection: application to the detection of gene amplification in breast cancer. International Journal of Cancer, 78:661-666, 1998.
Berndt, C. et al. Quantitative polymerase chain reaction using a DNA hybridization assay based on surface-activated microplates. Analytical Biochemistry, 225:252-257, 1995.
Gold, Larry. Oligonucleotides as research, diagnostic, and therapeutic agents. The Journal of Biological Chemistry, 270(23):13581-13584, 1995.
Greenspan, N.S. et al. Idiotypes: structure and immunogenicity. FASEB J, 7:437-444, 1993.
Huang, S.-C. et al. Binding of biotinylated DNA to streptavidin-coated polystyrene latex: effects of chain length and particle size. Analytical Biochemistry, 237:115-122, 1996.
Male, D. et al. (1987) Advanced Immunology, Gower Medical Publishing, London, U.K.
Mandal, S.S. et al. Role of the central metal ion and ligand charge in the DNA binding and modication by metallosalen complexes. Bioconjugate Chemistry, 8:798-812, 1997.
Drolet et al. An enzyme-linked oligonucleotide assay. Nature Biotechnology (1996), vol. 14, pp. 1021-1025.
Freytag et al., A highly sensitive affinity-column-mediated immunometric assay, as exmplified by digoxin. Clinical Chemistry (1984), vol. 30, No. 3, pp. 417-420.
Wang et al. RNA molecules that specifically and stoichiometrically bind aminoglycoside antibiotics with high affinities. Biochemistry (1996), vol. 35, pp. 12338-12346.
Hirayama et al. “Concentrations of Thrombopoietin in Bone Marrow in Normal Subjects and in Patients with Idiopathic Thrombocytopenic Purpura, Aplastic Anemia and Essential Thrombocythemia Correlate With Its mRNA Expression of Bone Marrow Stromal Cells”Blood92(1): 46-52 (1998).
Desjardin et al. “Comparision of the ABI 7700 System (TaqMan) and Competitive PCR for Quantification of IS6110 DNA in Sputum during Treatment of Tuberculosis”Journal of Clinical Microbiology36(7):1964-1976 (1998).
Gibson, U. et al. “A Novel Method for Real Time Quantitative RT-PCR,”Genome Research6:995-1001 (1996).
Piatak et al. “Quantitative Competive Polymerase Chain Reaction for Accurate Quantitation of HIV DNA and RNA Species”BioTechniques14:70-81 (1993).
Kaucner, C., et al “Sensitive and Rapid Detection of ViableGiardiaCysts andCryptospordium parvumOocycsts in Large-Volume Water Samples with Would Fiberglass Cartridge Filters and Reverse Transcription-PCR”,Applied and Environmental Microbiology, May 1998, pp. 1743-1749.

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