Quantitative analysis of free fatty acid and reagent composition

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

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435 25, 435 27, 435 28, 435189, 435810, 435923, 435924, C12Q 100, C12Q 126

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043012442

ABSTRACT:
There is provided a method for the quantitative analysis of a free fatty acid which comprises (1) the first step of treating a sample containing the free fatty acid with acyl-coenzyme A synthetase in the presence of adenosine triphosphate and coenzyme A to form acyl-coenzyme A, (2) the second step of oxidizing said acyl-coenzyme A, in the presence of oxygen, with acyl-coenzyme A oxidase produced by a microorganism of the genus Candida to form enoyl-coenzyme A and hydrogen peroxide, and (3) the third step of (a) measuring the amount of the formed enoyl-coenzyme A or hydrogen peroxide or (b) measuring the amount of oxygen consumed in said oxidation reaction, to thereby determine the amount of free fatty acid in said sample.

REFERENCES:
patent: 3979262 (1976-09-01), Hunziker
patent: 4071413 (1978-01-01), Takahashi et al.
patent: 4101381 (1978-07-01), Klose et al.
patent: 4229538 (1980-10-01), Yamada et al.
Chemical Abstracts, 89:159269d, "Acyl-CoA Oxidase of Rat Liver", p. 220, 1978.
Chemical Abstracts, 85:188245r, A Soluble-Coenzyme A Oxidase from the Yeast Candida utilis, 1976.
Chemical Abstracts, 90:135464h, Subcellular Distribution of the Enzymes of Fatty Acyl-CoA B-Oxidation System, 1979.
Takahashi et al. "Rinsho Kagaku", 4, 1975, pp. 179-185.

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