Quantitation of sample properties using contrast enhancement...

Details Quantitation of sample properties using contrast enhancement... Quantitation of sample properties using contrast enhancement...

2005-12-08

2009-10-27

Smith, Ruth S (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C324S307000, C324S309000

Reexamination Certificate

active

07610077

ABSTRACT:
The manipulation of RF irradiation to a subject in which a CEST agent has been administered is employed to determine a biological parameter in vivo in conjunction with an MRI imaging process. The exchange rate of the CEST agent is determined through RF manipulation which in turn enables the determination of a biological parameter through standard calibration techniques. The exchange rate of CEST agents is modulated as a function of many biological parameters, such as pH. MRI apparatuses and computer program products configured for determining exchanges rates of CEST agents in vivo are also disclosed.

REFERENCES:
patent: 2005/0059881 (2005-03-01), Balaban et al.
patent: 2005/0191243 (2005-09-01), Aime et al.

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