Quantitation of chromatographic information

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73 231, 364497, 36457105, 36457102, G06F 1546, G01N 3002

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048377260

ABSTRACT:
A process and apparatus for quantitating chromatographic information uses a discrete, linear, translation invariant filter function a.sub.N.sup..alpha., where N is a measure of the filter function width and .alpha. is a parameter whose value determines signal to noise characteristics of the filter function. First a chromatographic analysis of a sample is performed to obtain a first chromatogram. Then the first chromatogram is filtered with the filter function, with N set to approximate the width of peaks obtained in the first chromatogram, and .alpha. is set to filter out high frequency noise from the first chromatogram to obtain a second chromatogram having a first filtered baseline. The second chromatogram is then filtered with .alpha. set to resolution enhance peaks in the second chromatogram to obtain a third chromatogram having a baseline which is substantially the same as the first filtered baseline. The second chromatogram is then subtracted from the third chromatogram to obtain a fourth chromatogram which is baseline corrected.

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