Pyruvatekinase-iosenzyme typ-M2 (Tumor-M2-PK)-specific antibody/

Details Pyruvatekinase-iosenzyme typ-M2 (Tumor-M2-PK)-specific antibody/ Pyruvatekinase-iosenzyme typ-M2 (Tumor-M2-PK)-specific antibody/

1994-09-09

1999-10-26

Schwadron, Ronald B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 72, 435 74, 435 792, 435 793, 435 794, 435 795, 435975, 435330, 435337, 435338, 435344, 4353441, 53038826, 53038825, 5303913, 530808, 530809, 5303888, 53038885, 5303897, 436518, 436536, 436811, G01N 3353, G01N 33574, C07K 1640, C12N 520

Patent

active

059726288

ABSTRACT:
A qualitative, quantitative, as well as local determination of pyruvatkinase (ATP:pyruvate-2-O-phosphotransferase, EC 2.7.1.40)-isoenzyme typ M2 (Tumor-M2-PK) is possible in blood, plasma, tissue culture, tissue sections as well as in the animal and human organism with the help of antibodies.
Corresponding antisera are obtained if highly purified pyruvatekinase-isoenzymes type M2 (Tumor-M2-PK) or fragments of these, are used as immunogen. Preferable are antisera with monoclonal antibodies.
These antibodies can be used in ELISA-Test systems for the diagnosis of cancer, to determine the malignancy of cells, to localize a tumor in an organism as well as for the therapy of cancer.

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