Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1996-03-18
1997-09-16
Richter, Johann
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
560155, C07C22930, A01N 102
Patent
active
056679629
ABSTRACT:
The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia. The novel pyruvate compound is particularly a pyruvate thiolester. Preferably, the thiol is selected from a cysteine or a methionine amino acid. In a particularly preferred form, the compound is an N-acetyl ethyl ester of the cysteine or methionine amino acid. The most preferred compound is: ##STR1##
REFERENCES:
patent: 4970143 (1990-11-01), Guidoux et al.
patent: 5075210 (1991-12-01), Wikman-Coffelt
patent: 5283260 (1994-02-01), Miller et al.
patent: 5294641 (1994-03-01), Stanko
Federation Proceedings, vol. 46, No. 7, May, 1987, "Free Radical Scavengers in Myocardial Ischemia", by Paul J. Simpson, et al.
Free Radical Biology & Medicine, vol. XX, No. X, 1995, "Effects of N-Acetylcysteine in the Rat Heart Reperfused After Low-Flow Ischemia: Evidence for a Direct Scavenging of Hydroxyl Radicals and a Nitric Oxide Dependent Increase in Coronary Flow", by Julie Brunet , et al.
Ann. Surg., vol. 209, No. 5, May, 1990, "Effect of Pyruvate on Regional Ventricular Function in Normal and Stunned Myocardium", by mentzer, et al.
Molecular and Cellular Biochemistry, 22: 93-100 "Effect of Pyruvate on Rat Heart Thiol Status During Ischemia and Hypoxia Followed by Reperfusion", By Maria Pia Rigobello and Alberto Bindoli, Jan., 1993.
J. Thorac Cardiovasc Sug., 1991; 101:509-16, "Alcohol and Pyruvate Cardioplegia", by Ann Wikman-Coffelt, et al.
The New England Journal of Medicine, vol. 324, No. 26, "Improvement by Acetylcysteine of Hemodynamics and Oxygen Transport in Fulminant Hepatic Failure", by Phillip Harrison, et al., Jun., 1991.
Bomont Catherine
Brunengraber Henri
Dugas Hermann
Quinze Khadija
Case Western Reserve University
Oswecki Jane C.
Richter Johann
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