Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1997-02-27
1999-03-02
Richter, Johann
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
435 11, 514506, 514513, 514529, 514546, 560155, 560174, 5625124, 562578, A01N 102, A61K 31225, C07C 5919, C07C 69003
Patent
active
058769161
ABSTRACT:
The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs, ethanol intoxication or as a foodstuff. The novel pyruvate compound is particularly a pyruvate thiolester, a glycerol-pyruvate ester or a dihydoxyacetone-pyruvate ester.
REFERENCES:
Hart, Hart and Crane, Organic Chemistry, 9.sup.th Ed., 1995, p. 301.
Effects of Pyruvate and Dihydroxyacetone Consumption on the Growth and Metabolic State of Obese Zucker Rats.sup.1-3 Am J Clin Nutr 1991;53:847-53. 1991 American Society for Clinical Nutrition.
Inhibition of Lipid Accumulation and Enhancement of Energy Expenditure by the Addition of Pyruvate and Dihydroxyacetone to a Rat Diet Metabolism, vol., 35, No. 2 (Feb.), 1986: pp. 182-186.
Body Composition, Energy Utilization, and Nitrogen Metabolism with a 4.25-MJ/d Low-Energy Diet Supplemented with Pyruvate.sup.1-3 Am J Clin Nutr 1992;56:630-5, 1992 American Society for Clinical Nutrition.
Enhancement of Arm Exercise Endurance Capacity with Dihydroxyacetone and Pyruvate 0161-7567/90 1990 the American Physiological Society.
Enhanced Leg Exercise Endurance with a High-Carbohydrate Diet and Dihydroxyacetone and Pyruvate 0161-7567 1990 the American Physiological Society.
Reduction of Carcass Fat in Swine with Dietary Addition of Dihydroxyacetone and Pyruvate.sup.1 J Anim. Sci 1989. 67:1272-1278.
Body Composition, Energy Utilization, and Nitrogen Metabolism with a Severely Restricted Diet Supplemented with Dihydroxyacetone and Pyruvate.sup.1-3 Am J Clin Nutr 1992;55:771-6 1992 American Society for Clinical Nutrition.
Blood Glucose Extraction as a Mediator of Perceived Exertion During Prolonged Exercise European Journal of Applied Physiology and Occupational Physiology (1990) 61:100-105.
Bomont Catherine
Brunengraber Henri
David France
Hallowell Peter T.
Case Western Reserve University
Oswecki Jane C.
Richter Johann
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