Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-09-04
1985-10-08
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546208, A61K 31445, C07D40112
Patent
active
045461058
ABSTRACT:
This invention relates to pyrrolylaminopiperidines and related compounds of the formula ##STR1## where R is hydrogen, loweralkyl, Arloweralkyl, cycloalkylloweralkyl, loweralkenyl and thienylloweralkyl; R.sub.1 loweralkyl, hydrogen, loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl of the formula ##STR2## cyano, loweralkylaminocarbonyl, diloweralkylaminocarbonyl, cycloalkylcarbonyl, cycloalkylloweralkylcarbonyl and loweralkenylcarbonyl; R.sub.2 is hydrogen, halogen and methyl; and the pharmaceutically acceptable acid addition salts thereof.
REFERENCES:
patent: 4452803 (1984-06-01), Effland et al.
Flitsch et al., "Chem. Ber.", vol. 102, pp. 3268-3276 (1969), (and English Translation).
Johnson et al., "J. Med. Chem.", vol. 24, pp. 1314-1319 (1981).
Scheibye et al., "Bull. Soc. Chem. Belg.", vol. 87, pp. 229-238 (1978).
Niemegeers et al., "Arzneim-Forsch", vol. 36, pp. 1551-1556 (1976).
Epton, "Chem. and Industry", pp. 425-426 (1965).
Janssen et al., "Arzneim-Forsch", vol. 13, pp. 502-507 (1963).
Lobbezoo et al., "J. Med. Chem., vol. 24, pp. 777-782 (1981).
Effland Richard C.
Klein Joseph T.
Bond Robert T.
Hoechst-Roussel Pharmaceuticals Inc.
Wittekind Raymond R.
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