Pyrrolydine derivatives as IAP inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C546S277400, C546S273400, C435S375000

Reexamination Certificate

active

08044209

ABSTRACT:
The present invention relates to novel IAP inhibitor compounds of: Formula (I).

REFERENCES:
patent: 2006/0167066 (2006-07-01), Cohen et al.
patent: WO 01/90070 (2001-05-01), None
patent: WO 2004/005248 (2004-01-01), None
patent: WO 2004/007529 (2004-01-01), None
patent: WO 2005/097791 (2005-10-01), None
patent: WO 2006/014361 (2006-02-01), None
patent: WO 2006/069063 (2006-06-01), None
patent: WO 2007/106192 (2007-09-01), None
Arnt et al., “Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ”, Journal of Bilogical Chemistry, 2002 vol. 277 No. 46 pp. 44236-44243.
Deal et al., “Conformationally Constrained Tachykinin Analogues: Potent and Highly Selective Neurokinin NK-2 Receptor Agonists”, Journal of Medicinal Chemistry, 1992 vol. 35 pp. 4195-4204.
Kipp et al., “Molecular Targeting of Inhibitor of Apoptosis Proteins Based on Small Molecule Mimics of Natural Binding Partners”, Biochemistry, 2002 vol. 41 pp. 7344-7349.
Stables et al., “GR138676, A Novel Peptidic Tachykinin Antagonist Which is Potent at NK3 Receptors”, Neuropeptides, 1994 vol. 27 pp. 333-341.
Wu et al., “Structural Analysis of a Functional DIAP1 Fragment Bound to Grim and Hid Peptides”, Molecular Cell, 2001 vol. 8 No. 1 pp. 95-104.

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