Pyrrols [3,4-8]pyrazine derivatives, their production and use as

Details Pyrrols [3,4-8]pyrazine derivatives, their production and use as Pyrrols [3,4-8]pyrazine derivatives, their production and use as

1988-09-08

1989-11-07

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 5142342, 5142352, 514252, 514254, 514300, 514314, 514322, 514365, 514367, 514368, 514370, 540596, 540599, 540600, 544117, 544238, 544295, 544331, 544333, 544350, 544357, 544360, 544362, 544363, 544364, 544368, 544369, 544405, 546122, 546167, 546193, 546198, 546199, 546200, 546270, 548159, 548181, 548453, 548454, 548468, 548470, 548471, 548472, 548482, A61K 31535, A61K 31505, A61K 3150, A61K 31495, A61K 31445, A61K 3144, A61K 3140, A61K 3141, A61K 3147, C07D40110, C07D41314, C07D40914

Patent

active

048792934

ABSTRACT:
The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH.dbd.CH--CH.dbd.CH--, --S--(CH.sub.2).sub.l --S-- is an integer of 1 to 3), --N.dbd.CH--CH.dbd.N-- or --(CH.sub.2).sub.m --(m is an integer of 3 to 5); ring A may optionally be substituted with halogen, nitro, amino, alkanoylamino, alkoxycarbonyl, carboxyl or carbamoyl; and n is an integer of 1 to 3, and salts thereof. The compounds display a strong antianxiety effect to mammalian animals and are useful for the prevention or treatment of a disease such as psychoromatic disease and anxiety neurosis.

REFERENCES:
patent: 4788191 (1988-11-01), Hiraga et al.
S. Garbriel et al., Chem. Ber. 40, 4850-4861 (1907).
Richard Pater, J. Heterocycl. Chem. 7, 1113-1124 (1970).
Horii et al., J. Org. Chem. 26, 2273-2276 (1961).
Schweizer, Helv. Chim. Acta., vol. 52, Fasc. 8 (1969).
Matsui et al., Chem. Abst. 78-97477g (1973).
Jeanmart et al., Chem. Abst. 87-184560h (1977).

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