Pyrrolotriazine inhibitors of kinases

Details Pyrrolotriazine inhibitors of kinases Pyrrolotriazine inhibitors of kinases

2006-09-26

2006-09-26

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C514S243000

Reexamination Certificate

active

07112675

ABSTRACT:
The present invention provides compounds of formula Iand pharmaceutically acceptable salts thereof.The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

REFERENCES:
patent: 4908056 (1990-03-01), Tseng
patent: 5686457 (1997-11-01), Traxler et al.
patent: 6787545 (2004-09-01), Ohtani et al.
patent: 2003/0069244 (2003-04-01), Leftheris et al.
patent: 778 277 (1997-06-01), None
patent: 0 795 556 (1997-09-01), None
patent: WO 98/08847 (1998-03-01), None
patent: WO 01/14378 (2001-03-01), None
Patil et al., Journal of Heterocyclic Chemistry 31(4), 781-786, 1994.
Ewald, H., et al. “Reactionen von 1,2,4-Triazinen mit Acetylendlcarbonsaure-dimethylester”, Justus Liebigs Annalen Der Chemie, (1977), vol. 10, pp 1718-1724.
Otter et al., Nucleoside & Nucleotides, 15(1-3), 793-807 (1996).
Quintela et al., Tetrahedron 52(8), 3037-3048 (1996).
Patil et al., J. Heterocyclic Chem., 31(4), 781-807 (1994).
Neunhoeffer et al., Justus Liebigs Ann. Chem., vol. 9, 1413-1420 (1977) & Chem Abstr. 88:121113q, (Apr. 1978).
Skobe et al. Nature Medicine, vol. 3, No. 11, 1223-1227 (Nov. 1997).

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