Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-11-20
2007-11-20
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S183000
Reexamination Certificate
active
11426479
ABSTRACT:
The present invention provides compounds of formula Iand pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
REFERENCES:
patent: 6670357 (2003-12-01), Leftheris et al.
patent: 6787545 (2004-09-01), Ohtani et al.
patent: 6867300 (2005-03-01), Godfrey, Jr. et al.
patent: 6869952 (2005-03-01), Bhide et al.
patent: 6908916 (2005-06-01), Mastalerz et al.
patent: 6916815 (2005-07-01), Vite et al.
patent: 7064203 (2006-06-01), Gavai et al.
patent: 7102001 (2006-09-01), Swaminathan et al.
patent: 7102002 (2006-09-01), Cai et al.
patent: 7102003 (2006-09-01), Gavai et al.
patent: 2003/0232831 (2003-12-01), Dyckman et al.
patent: 2003/0232832 (2003-12-01), Lombardo et al.
patent: 2004/0063707 (2004-04-01), Bhide et al.
patent: 2004/0063708 (2004-04-01), Bhide et al.
patent: 2004/0077858 (2004-04-01), Bhide et al.
patent: 2004/0229877 (2004-11-01), Leftheris et al.
patent: 0 713 876 (1996-05-01), None
patent: WO 98/08847 (1998-03-01), None
patent: WO 00/71129 (2000-11-01), None
patent: WO 02/40486 (2002-05-01), None
patent: WO 03/090912 (2003-11-01), None
patent: WO 2004/009784 (2004-01-01), None
Tsi-Ping et al., TIPS 16: 57.66, 1995.
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
U.S. Appl. No. 60/620,784, filed Oct. 21, 2004, Gaval et al.
Ewald, H. et al., “Reaktionen von 1,2,4-Triazinen mit Acetylendicarbonsäure-dimethylester”, Liebigs Ann. Chem., pp. 1718-1724 (1977).
Hunt, J.T. et al., “Discovery of the Pyrrolo[2,1-f][1,2,4]triazine Nucleus as a New Kinase Inhibitor Template”, J. Med. Chem., vol. 47, No. 16, pp. 4054-4059 (2004).
Migliara, O. et al., “Synthesis of a New Bridgehead Nitrogen Heterocyclic System. Pyrrolo[2,1-f]-1,2,4-triazine Derivatives”, J. Heterocyclic Chem., vol. 16, pp. 833-834 (1979).
Neunhoeffer, H. et al., “Cycloadditionen mit Methoxy- und Dialkylamino-1,2,4-triazinen”, Liebigs Ann. Chem., pp. 1413-1420 (1977).
Patil, S.A. et al., “Synthesis of Pyrrolo[2,1-f][1,2,4]triazine Congeners of Nucleic Acid PurinesviatheN-Amination of 2-Substituted Pyrroles”, J. Heterocyclic Chem., vol. 31, pp. 781-786 (1994).
Quintela, J.M. et al., “A Ready One-pot Preparation for Pyrrolo[2,1-f][1,2,4]triazine and Pyrazolo[5,1-c]pyrimido[4,5-e]-[1,2,4]triazine Derivatives”, Tetrahedron, vol. 52, No. 8, pp. 3037-3048 (1996).
Chen Ping
Fink Brian E.
Gavai Ashvinikumar V.
Han Wen-Ching
Mastalerz Harold
Balasubramanian Venkataraman
Bristol--Myers Squibb Company
Korsen Elliott
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