Pyrrolothiazine and pyrrolothiazepine compounds having...

Details Pyrrolothiazine and pyrrolothiazepine compounds having... Pyrrolothiazine and pyrrolothiazepine compounds having...

2006-06-06

2006-06-06

Lambkin, Deborah C. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C544S048000, C548S541000

Reexamination Certificate

active

07057036

ABSTRACT:
A pyrrolesulfonamide derivative having the following formula (I):wherein the ring P represented byis a pyrrole ring having the following structure:wherein R represents alkyl, cycloalkyl, cycloalkyl-alkyl or aralkyl; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2is not present and Z1represents H but, when the bond is absent, Z1represents H and Z2represents OH or Z1and Z2are combined together to represent O or a group NOR1, in which R1represents H, or alkyl, aralkyl or aryl; l stands for 0 or 1; A represents alkylene, alkenylene or alkynylene; and Y represents a groupin which W represents CH, C═ or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C═; B represents a specific divalent group; E1and E2each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is useful as a therapeutic for circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturbances.

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