(Pyrroloquinoxalinyl) pyrazinecarbohydrazide-oxalic acid...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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C514S250000

Reexamination Certificate

active

08058437

ABSTRACT:
A novel co-crystal of N′-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when administered as a suspension.

REFERENCES:
patent: 2006/0142294 (2006-06-01), Neamati et al.
patent: 2006/0235034 (2006-10-01), Neamati
Dermer, G.B. Bio/Technology, 1994, 12:320.
Sausville et al. Cancer Research, 2006, vol. 66, pp. 3351-3354.
Johnson et al. British J. of Cancer, 2001, 84(10):1424-1431.
Grande et al. Bioorganic & Medicinal Chemistry, 2007, vol. 15, pp. 288-294.
Stahl et al., “Handbook of Pharmaceutical Salts: Properties, Selection, and Use.” (2002).
International Search Report and Written Opinion issued in International application No. PCT/US09/39961 on May 20, 2009.

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