Pyrroloquinoline quinone-dependent glucose dehydrogenase

Details Pyrroloquinoline quinone-dependent glucose dehydrogenase Pyrroloquinoline quinone-dependent glucose dehydrogenase

2006-05-02

2006-05-02

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S189000, C435S069100, C435S320100, C435S252300, C536S023200

Reexamination Certificate

active

07037698

ABSTRACT:
A modified pyrroloquinoline quinone-dependent glucose dehydrogenase having a low reactivity with respect to maltose, galactose, etc. is provided. A modified pyrroloquinoline quinone-dependent glucose dehydrogenase including an amino acid sequence in which one or more amino acids in a region corresponding to a first region consisting of amino acids at positions 326 to 354 in pyrroloquinoline quinone-dependent glucose dehydrogenase derived fromAcinetobacter calcoaceticusare substituted as compared with an amino acid sequence of the corresponding wild-type enzyme.

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A.M.-Cleton-Jansen, et al.; Cloning, characterization and DNA sequencing of the gene encoding the Mr50 000 quinoprotein glucose dehydrogenase fromAcinetobacter calcoaceticus; Mol Gen Genet; vol. 217; 1989, pp. 430-436./Discussed in the specification.
European Search Report mailed Oct. 6, 2004.

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