Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-01-19
1990-02-06
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 84, A61K 3147
Patent
active
048988707
ABSTRACT:
The present invention concerns an enzyme inhibitor containing the compound represented by the following formula (I) as an effective ingredient: ##STR1## where R represents hydrogen or substituted or not substituted alkyl group, alkenyl group, aryl group or aralkyl group, X represents OR' or NR"R"', in which R', R" and R'" represent respectively hydrogen or substituted or not substituted alkyl group, alkenyl group, aryl group or aralkyl group.
The enzyme inhibitor according to the present invention can effectively inhibit aldose reductase, glyoxalase I and reverse transcriptase.
REFERENCES:
Duine et al., European Journal of Biochemistry, vol. 108, pp. 187-192, 1980.
Chem. Abstr., vol. 93, No. 7,. 93:64554m, p. 376, Aug. 18, 1980.
Dvornik, "Aldose Reductase Inhibition", Chapter 5, pp. 328-353, 1987.
Katsumata Manabu
Narutomi Yuji
Osawa Yasuko
Uchikuga Saburo
Lee Mary C.
Northington-Davis Zinna
Sogo Pharmaceutical Company Limited
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