Pyrrolopyrimidinyalglutaminate derivatives and their use

Details Pyrrolopyrimidinyalglutaminate derivatives and their use Pyrrolopyrimidinyalglutaminate derivatives and their use

1992-08-07

1995-04-04

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, 514212, 514252, 514255, 540452, 540465, 540481, 540485, 540486, 540600, 544116, 544117, 544238, 544253, 544280, A61K 31505, C07D48704

Patent

active

054038430

ABSTRACT:
A condensed pyrimidine derivative of the formula (I): ##STR1## wherein the ring A stands for an optionally substituted 5-membered ring; B stands for an optionally substituted divalent 5- or 6-membered homo- or hetero-cyclic group; X stands for, among others, amino group; Y stands for, among others, hydrogen atom, halogen atom or amino group; Z stands for a divalent aliphatic group having five or less atoms forming straight chain, optionally having nitrogen, whose chain portion may optionally have a hetero-atom; W stands for, among others, --NH--CO-- or --CO--NH--; R.sup.1 stands for an optionally substituted cyclic or chain-like group; COOR.sup.2 stands for an optionally esterified carboxyl group; and p denotes an integer of 1 to 4, provided that when --W--R.sup.1 denotes a moiety represented by the formula: ##STR2## wherein COOR.sup.16 and COOR.sup.17 are, independently, an optionally esterified carboxyl group and n denotes an integer of 1 to 5, p denotes 1, 3 or 4, or a salt thereof, exhibiting highly specific toxicities to various tumor cells and excellent therapeutic effects on methotrexate-resistant tumor cells as well.

REFERENCES:
patent: 4767761 (1988-08-01), Rosowsky
patent: 4895946 (1990-01-01), Taylor et al.
patent: 4946846 (1990-08-01), Nomura et al.
patent: 4996206 (1991-02-01), Taylor et al.
patent: 4997838 (1991-03-01), Akimoto et al.

Affiliated with

Also associated with

Rating

Pyrrolopyrimidinyalglutaminate derivatives and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrolopyrimidinyalglutaminate derivatives and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolopyrimidinyalglutaminate derivatives and their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2380848