Pyrrolopyrimidines and related analogs as HSP90-inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S280000

Reexamination Certificate

active

07138402

ABSTRACT:
The present invention provides compounds represented by Formula I. R0is selected from hydrogen, halogen, lower alkyl, —SR8, —OR8, —CN, and —NHR8, R1is halogen, or lower alkyl; R2is —NHR8; R3is selected from the group consisting of hydrogen, halogen, —SR8, —OR8, —CN, —C(O)R9, —C(O)OH, —NO2, —NR8R10, lower alkyl, lower alkenyl, lower alkynyl, lower perhaloalkyl, aryl, heteroaryl, alicyclic and heterocyclic, all optionally substituted, and R5is aryl, heteroaryl, alicyclic, or heterocyclic:

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