Pyrrolopyrimidine derivatives, their production and use

Details Pyrrolopyrimidine derivatives, their production and use Pyrrolopyrimidine derivatives, their production and use

1989-03-21

1991-03-05

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544280, A61K 31505, C07D48704

Patent

active

049978381

ABSTRACT:
A compound of the formula ##STR1## wherein the ring .circle.A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.

REFERENCES:
patent: 4532241 (1985-07-01), DeGraw et al.
patent: 4684653 (1987-08-01), Taylor et al.

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