Pyrrolopyrimidine derivatives, their production

Details Pyrrolopyrimidine derivatives, their production Pyrrolopyrimidine derivatives, their production

1993-12-06

1996-07-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D48702

Patent

active

055391133

ABSTRACT:
A process of making a compound of the formula ##STR1## wherein the ring A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.

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Journal of Medicinal Chemistry, vol. 28, 914-921 (1985) Taylor et al.
Journal of Medicinal Chemistry, Winstock et al., 13(5), 1970, 995-997.
CA 99:70481 A, 1983 Nishimura et al.

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