Pyrrolopyridazine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S116000, C544S235000, C514S248000

Reexamination Certificate

active

11500293

ABSTRACT:
The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3and R4are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases

REFERENCES:
patent: 6472389 (2002-10-01), Ohtani et al.
patent: 2 792 938 (2000-11-01), None
patent: WO 91/18903 (1991-12-01), None
patent: WO 9118903 (1991-12-01), None
patent: 03/082208 (2003-10-01), None
Cecil Textbook of Medicine (20th Edition, vol. 2), 1996, pp. 1739-1747.
Aoki et al. The Journal of Pharmacology and Experimental Therapeutics, vol. 298, No. 3, pp. 1142-1149.
Duan et al. (abstract of Chin J. Hepatol., Aug. 2003, vol. 11, No. 8, 493-496).
Ichiyama et al, Scand. J. Infect. Dis., 35:59-61 (2003).
Kawada et al, J. Infect. Dis. 2003, 188(5): 690-698).
Landellls et al. British Journal of Pharmacology (2001) 133, 722-729.
W. Flitsch, et al., Tetrahedron Letters, vol. 12, XP-002273465, pp. 1479-1484, “Synthesen und Reaktionen von 5-Aza-Indolizinen und 5-Aza-Cycl(3.2.2)Azin-Derivaten”, 1968.
Cecil Textbook of Medicine (20thEdition, vol. 2), 1996, pp. 1739-1747.
Flitsch et al. Tetrahedron Letters (1968), (12), 1479-84.
Takashi Ichiyama, et al., “Cerebrospinal Fluid and Serum Levels of Cytokines and Soluble Tumor Necrosis Factor Receptor Influenza Virus-associated Enciphalopathy”, Scand J Infect Dis, Taylor & Francis Healthsciences, vol. 35, pp. 59-61.
Jun-Ichi Kawada, et al., “Systemic Cytokine Responses in Patients with Influenza-Associated Enciphalopathy”, Major Article, Sep. 1, 2003, pp. 690-698.
Duan Zhong-Ping, et al., “Clinical Characteristics and Mechanism of Liver Injury in Patients with Severe Acute Respiratory Syndrome”, Chin J. Hepatol, vol. 11, No. 8, Aug. 2003, pp. 493-496.
Landellls et al., British Journal of Pharmacology (2001) 133, 722-729.
STN Search Printout (p. 66-70), from wo 91/18903, 1991.
Mark Glembycz, Current Opinion in Pharmacology, 2005, 5:238-244.

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