Pyrroloisoquinolines useful as hypercholesterolemic and hyperlip

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 94, A61K 3147, C07D47104

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active

049333500

ABSTRACT:
Pyrrolo[2,1-a]isoquinoline derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each represent cycloalkyl or alkyl, alkenyl or alkynyl which may be halogen-substituted, or optionally substituted aryl or heteroaryl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

REFERENCES:
patent: 3019232 (1982-01-01), Sakorai et al.
March, J., Advanced Organic Chemistry, 3rd ed. (1985), pp. 333-336, 348-349, 691-696, 809-811, 1057-1059.
Journal of Organic Chemistry, vol. 47, No. 1982.
Journal of Medicinal Chemistry, vol. 11, 1968.

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