Pyrrolobenzoxazines, pyrrolobenzothiazines and process therefor

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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42424856, 260243R, 260244R, 2602475FP, A61K 3154, A61K 31535, C07D26528, C07D27916

Patent

active

040354954

ABSTRACT:
4H-Pyrrolo[2,1-c][1,4]benzoxazines and 4H-pyrrolo[2,1-c]-[1,4]benzothiazines characterized by having an alkylamine substituent at position 4 are disclosed. The compounds are characterized further by having an alkyl substituent on the same carbon atom bearing the alkylamine substituent. In addition the compounds may be optionally substituted at positions 1 and 6 to 9. Also disclosed are 4H-pyrrolo-[2,1-c][1,4]benzoxazines and 4H-pyrrolo[2,1-c][1,4]benzothiazines which are dialkylated at position 4 and have a methylamino substituent at position 1. The foregoing compounds possess antihypertensive and central nervous system depressant activity and methods for their preparation and use are described.

REFERENCES:
patent: 3829421 (1974-08-01), Irmscher et al.
patent: 3910901 (1975-10-01), Demerson et al.

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