Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-12-10
1989-09-05
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142268, 5142272, 5142285, 5142288, 5142308, 5142328, 514241, 514242, 514248, 514249, 514253, 514254, 514259, 514260, 514269, 514272, 514274, 514307, 514309, 514310, 514312, 514313, 514314, 514322, 514339, 514361, 514362, 514363, 514364, 514365, 514369, 514370, 514372, 514374, 514376, 514377, 514378, 514380, 514381, 514383, 514384, 544310, 544315, 544316, 544317, 544318, 544319, 544320, 544321, 544322, 544324, 544326, 544327, 544328, 544331, 544333, 544353, 544354, 544356, 544366, 544405, 544 60, 544139, 54
Patent
active
048639451
ABSTRACT:
Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R.sub.1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered heterocyclic group which can be condensed with a phenyl ring to form a bicyclic radical. R.sub.2 is hydrogen, alkyl, alkenyl or cycloalkenyl; R.sub.3 is alkyl, alkenyl or hydroxyalkyl or with R.sub.2 together forms cycloakylene; or R.sub.2 and R.sub.3 together form alkylidene or cycloalkylidene. R.sub.4 is hydrogen or lower alkanoyl. X is a valency bond, alkylene, vinylene, imino or carbonylamino. T stands for two hydrogen atoms. When X is a valency bond, R.sub.1 can also be hydrogen, hydrocarbyl which may also contain oxygen, amino, sulfur, carbonyl and sulfonyl groups. When X is imino or carbonylamino or when R.sub.1 is a bicyclic radical, T can also be oxygen. The compounds also include the tautomers and physiologically acceptable salts with inorganic and organic acids.
REFERENCES:
patent: 4666923 (1987-05-01), Holck et al.
patent: 4695567 (1987-09-01), Mertens et al.
patent: 4710510 (1987-12-01), Mertens et al.
Boehm Erwin
Friebe Walter-Gunar
Mertens Alfred
Strein Klaus
Boehringer Mannheim GmbH
Lee Mary C.
Richter J.
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