Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-02-07
1993-04-27
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540521, A61K 3155, C07D48704
Patent
active
052062392
ABSTRACT:
Disclosed herein are pyrroloazepine derivatives, which are useful as therapeutics for circulatory diseases, represented by the following formula (I): ##STR1## wherein R means a hydrogen atom, a linear or branched C.sub.1-6 alkyl group or a C.sub.7-10 aralkyl group, A denotes a linear or branched C.sub.2-10 alkylene, alkenylene or alkynylene group, Z stands for O, NOR.sub.1 or NOCOR.sub.5 in which R.sub.1 and R.sub.5 is a hydrogen atom or an alkyl, aryl or aralkyl group, and Y means a particular piperidinyl or pyrrolidinyl group; and salts thereof. Their preparation processes are also disclosed.
REFERENCES:
Aust. J. Chem., vol. 43, 1990, pp. 355-365, B. Kasum, et al., "Dihydroindol-7(6H)-Ones and 6,7-Dihydropyrrolo[2,3-C]Azepine-4,8(1H,5H)-Dione".
Utkina, Chem Abs 102, 146334 (1984).
de Nanteuil, Tetrahedron 41, 6028 (1985).
Sharma, J. C. S. Chemical Communications 435-6 (1980).
Cho Hidetsura
Hamaguchi Mikiko
Ishihara Takafumi
Mizuno Akira
Tatsuoka Toshio
Berch Mark L.
Suntory Limited
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