Pyrrolo-pyridine derivatives

Details Pyrrolo-pyridine derivatives Pyrrolo-pyridine derivatives

1994-02-22

1995-07-11

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544362, 544363, 544101, 544234, 5142298, A61K 31495, A61K 31535, C07D49802, C07D48700

Patent

active

054321778

ABSTRACT:
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D.sub.4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia while manifesting fewer side-effects than those associated with classical neuroleptic drugs.

REFERENCES:
patent: 3362956 (1968-01-01), Archer
patent: 3511841 (1970-05-01), Archer
Nature, vol. 350, pp. 610-614 by H. M. Van Tol et al. "Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine" Apr. 1991.
Nature, vol. 350, pp. 614-619 by R. K. Sunahara et al. "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine tha D1" Apr. 1991.
"2-Phenylpyrroles . . . ", Part II, J. Med. Chem. 1988, vol. 31, pp. 1934-1940, by I. V. Wijngaarden et al.
"2-Phenylpyrroles . . . ", Part I, J. Med. Chem. 1987, vol. 30, pp. 2099-2104, by I. V. Wijngaarden et al.

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