Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-02
1997-04-22
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514211, 5142302, 514250, 514253, 514254, 540548, 544101, 544344, 544362, 544363, A61K 31495, A61K 3150, C07D24136, C07D40100
Patent
active
056229500
ABSTRACT:
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D.sub.4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs.
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"2-Phenylpyrroles as Conformationally Restricted Benzamide Analogues.", Pt. 2, by I. Wijingaarden et al., J. Med. Chem., vol. 31, No. 11, pp. 1934-1940 (1988).
Baker Raymond
Curtis Neil R.
Kulagowski Janusz J.
Leeson Paul D.
Ridgill Mark P.
Merck Sharp & Dohme Ltd.
North Robert J.
Tsang Cecilia
Winokur Melvin
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