Pyrrolo isoquinolines

Details Pyrrolo isoquinolines Pyrrolo isoquinolines

1998-05-07

2000-12-19

Jones, Dameron

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 91, 424 165, 424 94, 546152, 548400, 534770, A61K 5100, A61M 3614

Patent

active

061624179

ABSTRACT:
Compounds of the formula: ##STR1## wherein X, Y, and R, independently of one another, is each a H; halogen, wherein said halogen is selected from the group consisting of .sup.123 I, .sup.124 I, .sup.125 I, .sup.131 I, .sup.75 Br, .sup.76 Br, .sup.77 Br, .sup.82 Br, .sup.18 F, or .sup.210 At; small alkyl, small alkenyl, or small alkynyl, any of which contains from one to about six carbon atoms and optionally having a carbon atom replaced by an O or S; or halogen substituted-small alkyl, halogen substituted-small alkenyl, or halogen substituted-small alkynyl wherein said compound contains at least one radioacitve halogen.
The compounds bind to the serotonin transporter. Depending upon the choice of halogen substituent, the compounds are useful for PET or SPECT imaging, diagnosis and treatment of psychiatric disorders such as depression, anxiety, obsessive-compulsive disorder, and other conditions associated with defects of serotonin transporter function.

REFERENCES:
Suehiro et al, Nucl. Med. Biol, 1996 23(4), pp. 407-412, "Radiosynthesis and Biodistribution of S-[78F]Fluoroethyl Analog of McN5652", May 1996.

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