Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs...

Details Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs... Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs...

2002-02-22

2009-12-01

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S433000, C548S429000, C514S411000, C514S292000

Reexamination Certificate

active

07626026

ABSTRACT:
Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, R1and optionally also R3preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which X is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumors. The prodrug is expected to be activated preferentially in tumor cells, where it will act as a DNA alkylating agent preventing cell division.

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