Pyrrolo[3,4-D]Pyrimidinone derivatives and their use as medicame

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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C07D48704

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active

061369748

ABSTRACT:
The invention provides certain novel 5-substituted pyrrolo[3,4-d]pyrimidine-2,4-diones, processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and methods of treatment involving their use.

REFERENCES:
Michne et al, "Novel Inhibitors of the Nuclear Factor of Activated T Cells (NFAT)-Mediated . . . ," J. Med. Chem., vol. 38, pp. 2557-2569 (1995).
Noguchi et al, "A Facile Preparation of 7-(Substituted amino)-6H-pyrrolo[3,4-d]-pyrimidine Derivatives.sup.1 ," Bull. chem. Soc. Jpn., vol. 62, pp. 3043-3045 (1989).
Hirota et al, "Pyrimidine Derivatives and Related Compounds. XXXIII..sup.1) Reactions of . . . , " Chem. Pharm. bull., Vol. 29, No. 6, pp. 1525-1532 (1981).
Senda et al, "A Facile Synthesis of Pyrrolo[3, 4-d]pyrimidines and Pyrimido[4,5-d]pyridazines," communications, "Synthesis, " pp. 463-465 (1978).
Baine et al, "functional characterization of Novel IL-2 Transcriptional Inhibitors," the Journal of Immunology, Vol. 154, pp. 3667-3677 (1995).

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