Pyrrolo[3,4-c]pyrazole derivatives active as kinase...

Details Pyrrolo[3,4-c]pyrazole derivatives active as kinase... Pyrrolo[3,4-c]pyrazole derivatives active as kinase...

2006-11-28

2006-11-28

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S254080, C514S322000, C544S140000, C544S143000, C544S371000, C544S373000, C546S199000

Reexamination Certificate

active

07141568

ABSTRACT:
Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

REFERENCES:
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Dermer (Biocechnology, 1994, 12:320).
Tanaka T. et al., “Centrosomal Kinase AIK1 is Overexpressed in Invasive Ductual Carcinoma of the Breast”,Cancer Research 59:2041-2044 (1999).
Cohen P., “The Development and Therapeutic Potential of Protein Kinase Inhibitors”,Current Opinion of Chemical Biology 3:459-465 (1999).
Sen S. et al., “Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer”,Journal of the National Cancer Institute 94(17):1320-1329 (2002).
Warner S.L. et al., “Targeting Aurora-2 Kinase in Cancer”,Molecular Cancer Therapeutics 2:589-595 (2003).

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