Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin...

Details Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin... Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin...

2002-06-11

2008-12-09

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S280000

Reexamination Certificate

active

07462622

ABSTRACT:
The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereofwhereinR is aryl or heteroaryl and each of the above groups R may be substituted by 1 to 4 groups selected from:halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, —COR4, nitro, —NR3R4cyano, or a group R5;R1is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkyl, halo C1-C6 alkoxy, halogen, NR3R4or cyano;R2corresponds to a group CHR6R7;R3is hydrogen, C1-C6 alkyl;R4independently from R3, has the same meanings;R5is C3-C7 cycloalkyl, which may contain one or more double bonds; aryl; or a 5-6 membered heterocycle; wherein each of the above groups R5may be substituted by one or more groups selected from: halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, C1-C6 dialkylamino, nitro or cyano;R6is hydrogen, C2-C6 alkenyl or C1-C6 alkyl, wherein each of the above groups R6may be substituted by one or more groups selected from: C1-C6 alkoxy and hydroxy;R7independently from R6, has the same meanings;X is carbon or nitrogen;to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF).

REFERENCES:
patent: 2004/0171607 (2004-09-01), DiFabio et al.
patent: 2004/0176400 (2004-09-01), Capelli et al.
patent: 48/2804 (1997-01-01), None
patent: WO 95/33750 (1995-12-01), None
patent: WO 99/11643 (1999-03-01), None
Ayala et al. (Exp. Opin. Ther. Patents, 2000, 10(1), 67-74).

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