Pyrrolo[2,3-d]pyrimidine and their use as purinergic...

Details Pyrrolo[2,3-d]pyrimidine and their use as purinergic... Pyrrolo[2,3-d]pyrimidine and their use as purinergic...

2006-08-29

2006-08-29

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

07098333

ABSTRACT:
Use of a compound of the formula (I) wherein R1is selected from alkyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, halogen, CN, NR7R8, NR6COR7, NR6CO2R9and NR6SO2R9; R2is selected from aryl attached via an unsaturated carbon; R3and R4are independently selected from H, alkyl, halogen, alkoxy, alkylthio, CN and NR7R8; R5is selected from H, acyclic alkyl, COR6, CONR7R8, CONR6NR7R8, CO2R9and SO2R9; R6, R7and R8are independently selected from H, alkyl and aryl or where R7and R8are in an NR7R8group R7and R8may be linked to form a hererocyclic group, or where R6, R7and R8are in a (CONR6NR7R8) group, R6and R7may be linked to form a hererocyclic group; and R9is selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or prodrug thereof, in the manufacture of a medicament for the treatment or prevention of a disorder in which the blocking of purine receptors, particularly adenosine receptors and more particularly A2Areceptors, may be beneficial, particularly wherein said disorder is a movement disorder such as Parkinson's disease or said disorder is depression, cognitive or memory impairment, acute or chronic pain, ADHD or narcolepsy, or for neuroprotection in a subject; compounds of formula (I) for use in therapy; and novel compounds of formula (I) per se

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